ENG/中
老虎證券
行情
交易
收費
下載
優惠與活動
幫助
TigerAI
學堂
期權訓練營
投資學堂
機構
財富及資產管理人
自營交易機構
介紹經紀商
三方服務商
股權激勵
關於
關於我們
媒體報道
獎項與榮譽
登入
立即註冊
Toggle
美股
詳情
本頁面由Tiger Trade Technology Pte. Ltd.提供服務
Ionis Pharmaceuticals, Inc
47.25
-4.1900
-8.15%
盤後：
47.98
0.7300
+1.54%
19:57 EDT
成交量：
681.25萬
成交額：
3.26億
市值：
78.52億
市盈率：
-13.58
高：
51.37
開：
51.37
低：
46.72
收：
51.44
52周最高：
86.74
52周最低：
46.72
股本：
1.66億
流通股本：
1.62億
量比：
1.45
換手率：
4.21%
股息：
- -
股息率：
- -
每股收益(TTM):
-3.4800
每股收益(LYR):
-2.3812
淨資產收益率：
-105.50%
總資產收益率：
-12.42%
市淨率：
17.86
市盈率(LYR):
-19.84
資料載入中...
總覽
公司
新聞資訊
公告
2021/02/12
超過5%披露
SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals
2021/02/10
超過5%披露
SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals
2021/02/09
超過5%披露
SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals
2021/02/08
超過5%披露
SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals
2021/02/05
超過5%披露
SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals
2021/01/14
SEC問詢函
CORRESP [Cover] - Correspondence
2020/12/31
員工持股計劃
S-8 - Securities to be offered to employees in employee benefit plans
2020/12/18
重要事件披露
8-K - Current report
2020/12/09
重要事件披露
8-K - Current report
2020/11/04
季度報告
10-Q - Quarterly report [Sections 13 or 15(d)]
2020/11/04
重要事件披露
8-K - Current report
2020/10/13
超過5%披露
SC 13D/A [Amend] - General statement of acquisition of beneficial ownership
2020/10/13
重要事件披露
8-K - Current report
2020/10/02
超過5%披露
SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals
2020/09/24
SEC問詢函
CORRESP [Cover] - Correspondence
2020/08/31
超過5%披露
SC 13D/A [Amend] - General statement of acquisition of beneficial ownership
2020/08/31
重要事件披露
8-K - Current report
2020/08/10
員工持股計劃
S-8 - Securities to be offered to employees in employee benefit plans
2020/08/05
季度報告
10-Q - Quarterly report [Sections 13 or 15(d)]
2020/08/05
重要事件披露
8-K - Current report
更多
{"basename":"/hant","ssrTDKData":{"titleTemplate":"%s - 老虎證券","title":"老虎證券香港 | 輕鬆買賣美股港股A股/美債/ETF/Crypto/期權期貨","description":"老虎證券香港提供多種優惠: 港股&Crypto 0佣、A股一年0佣、美股期權0佣、IPO抽新股0孖展利息0手續費。美股1美金起投，即時串流報價與多種工具，立即開戶享更多優惠！","keywords":"老虎證券,老虎證券開戶,老虎證券香港,老虎證券投資,老虎證券美股,老虎證券登錄,證券開戶,證券公司開戶,股票開戶,香港證券公司,香港證券,證券公司,美股投資平台,小額投資理財,投資app,投資平台,股票買賣,買賣股票平台,炒股app,證券app,新手投資","social":{"ogDescription":"老虎證券香港提供多種優惠: 港股&Crypto 0佣、A股一年0佣、美股期權0佣、IPO抽新股0孖展利息0手續費。美股1美金起投，即時串流報價與多種工具，立即開戶享更多優惠！","ogImage":"https://c1.itigergrowtha.com/portal5/static/media/og-logo.0a0bd8dc.png","ogUrl":"https://www.imtigers.com/hant/stock/IONS/filings?page=17"},"companyName":"老虎證券"},"pageData":{"isMobile":false,"isTiger":false,"isTTM":true,"region":"HKG","license":"TBHK","edition":"fundamental","symbol":"IONS","isAnalysisPage":false},"__swrFallback__":{"@#url:\"https://hq.skytigris.cn/stock_info/detail/global\",params:#delay:false,,method:\"POST\",data:#items:@#symbol:\"IONS\",,,,,undefined,":{"symbol":"IONS","market":"US","secType":"STK","nameCN":"Ionis Pharmaceuticals, Inc","latestPrice":47.25,"timestamp":1789502400000,"preClose":51.44,"halted":0,"volume":6812465,"hourTrading":{"tag":"盘后","latestPrice":47.98,"preClose":47.25,"latestTime":"19:57 EDT","volume":118240,"amount":5600833.0441,"timestamp":1789516638620,"change":0.73,"changeRate":0.01545,"amplitude":0.01545},"delay":0,"changeRate":-0.08145412130637632,"floatShares":161921007,"shares":166184322,"eps":-3.48,"marketStatus":"未開盤","change":-4.19,"latestTime":"09-15 16:00:00 EDT","open":51.37,"high":51.37,"low":46.715,"amount":325765761.144945,"amplitude":0.090494,"askPrice":0,"askSize":0,"bidPrice":0,"bidSize":0,"shortable":3,"etf":0,"ttmEps":-3.48,"tradingStatus":0,"nextMarketStatus":{"tag":"盤前交易","tradingStatus":1,"beginTime":1789545600000},"marketStatusCode":0,"adr":0,"adrRate":0,"exchange":"NASDAQ","adjPreClose":51.44,"preHourTrading":{"tag":"盘前","latestPrice":51.36,"preClose":51.44,"latestTime":"09:29 EDT","volume":2649,"amount":136416.74505,"timestamp":1789478955188,"change":-0.08,"changeRate":-0.001555,"amplitude":0.012241},"postHourTrading":{"tag":"盘后","latestPrice":47.98,"preClose":47.25,"latestTime":"19:57 EDT","volume":118240,"amount":5600833.0441,"timestamp":1789516638620,"change":0.73,"changeRate":0.01545,"amplitude":0.01545},"volumeRatio":1.454328,"impliedVol":0.5281,"impliedVolPercentile":0.8884},"@#url:\"https://hq.skytigris.cn/stock_info/fundamental/all\",params:#delay:false,,method:\"POST\",data:#items:@#symbol:\"IONS\",,,,,undefined,":{"symbol":"IONS","floatShares":161921007,"roa":"-12.42%","roe":"-105.50%","lyrEps":-2.38125,"volumeRatio":1.454328,"shares":166184322,"dividePrice":0,"high":51.37,"amplitude":0.090494,"preClose":51.44,"low":46.715,"week52Low":46.715,"pbRate":"17.86","psRate":"8.98","week52High":86.74,"institutionHeld":0.92,"latestPrice":47.25,"eps":-3.48,"divideRate":0,"volume":6812465,"delay":0,"ttmEps":-3.48,"open":51.37,"prevYearClose":79.11,"prevWeekClose":54.21,"prevMonthClose":60.36,"prevQuarterClose":79.29,"fiveDayClose":56.71,"twentyDayClose":58.63,"sixtyDayClose":74.12},"@#url:\"https://hq.skytigris.cn/fundamental/corporate_actions/details/IONS\",params:#limit:5,,,undefined,":[{"market":"US","date":"2026-07-29","symbol":"IONS","fiscalQuarterEnding":"2026/06","expectedEps":-1.09,"name":null,"time":"盤前","type":"earning","dateTimestamp":1785297600000,"reportTimeType":"pre","actualEps":-0.7},{"market":"US","date":"2026-04-29","symbol":"IONS","fiscalQuarterEnding":"2026/03","expectedEps":-0.89,"name":null,"time":"盤前","type":"earning","dateTimestamp":1777435200000,"reportTimeType":"pre","actualEps":-0.56},{"market":"US","date":"2026-02-25","symbol":"IONS","fiscalQuarterEnding":"2025/12","expectedEps":-1.31,"name":null,"time":"盤前","type":"earning","dateTimestamp":1771995600000,"reportTimeType":"pre","actualEps":-1.41},{"market":"US","date":"2025-10-29","symbol":"IONS","fiscalQuarterEnding":"2025/09","expectedEps":-1.23,"name":null,"time":"盤前","type":"earning","dateTimestamp":1761710400000,"reportTimeType":"pre","actualEps":-0.8},{"market":"US","date":"2025-07-30","symbol":"IONS","fiscalQuarterEnding":"2025/06","expectedEps":-0.11,"name":null,"time":"盤前","type":"earning","dateTimestamp":1753848000000,"reportTimeType":"pre","actualEps":0.7}],"@#url:\"https://hq.skytigris.cn/fundamental/dividend/history\",params:#symbol:\"IONS\",market:\"US\",,,undefined,":[],"@#url:\"https://hq.skytigris.cn/fundamental/estimate/recommendation\",params:#symbol:\"IONS\",market:\"US\",delay:false,,,undefined,":{"strongBuy":0.2308,"buy":0.5385,"hold":0.2308,"sell":0,"strongSell":0,"meanLabel":"BUY","meanPercent":0.5385,"analysts":26,"updateTime":1787112000000},"@#url:\"https://hq.skytigris.cn/value_analysis/stock/IONS\",params:#withQuantilePoint:true,period:\"5year\",factor:\"peRate\",delay:false,algorithm:1,,,undefined,":{"brief":{"id":"IONS","date":"2026-09-14","current":-13.577586,"percent":0.679414,"low":-1664.931905,"twenty":-46.83029,"median":-17.982683,"eighty":-11.698961,"high":882.260453,"avg":-65.178512,"sd":366.234285,"marketCap":9008852095},"quantilePoints":[{"date":"2021-09-17","current":-9.553748,"twenty":-43.823694,"median":22.105712,"eighty":90.484478,"marketCap":5252105842},{"date":"2021-09-24","current":-9.294428,"twenty":-43.823694,"median":21.894477,"eighty":89.822908,"marketCap":5109546667},{"date":"2021-10-01","current":-8.61917,"twenty":-43.823694,"median":21.739571,"eighty":88.160122,"marketCap":4738328221},{"date":"2021-10-08","current":-8.752681,"twenty":-43.823694,"median":21.475528,"eighty":87.371554,"marketCap":4811725024},{"date":"2021-10-15","current":-9.012001,"twenty":-43.823694,"median":21.145012,"eighty":86.264015,"marketCap":4954284199},{"date":"2021-10-22","current":-7.815535,"twenty":-43.823694,"median":21.004285,"eighty":84.663252,"marketCap":4296535927},{"date":"2021-10-29","current":-8.182691,"twenty":-43.823694,"median":20.82218,"eighty":83.19244,"marketCap":4498377135},{"date":"2021-11-05","current":-7.827936,"twenty":-43.823694,"median":20.669316,"eighty":82.070133,"marketCap":4757365405},{"date":"2021-11-12","current":-7.595584,"twenty":-43.823694,"median":20.616507,"eighty":76.079084,"marketCap":4616155390},{"date":"2021-11-19","current":-7.432938,"twenty":-43.823694,"median":20.366546,"eighty":75.49578,"marketCap":4517308379},{"date":"2021-11-26","current":-6.749823,"twenty":-43.823694,"median":20.294106,"eighty":74.547727,"marketCap":4102150935},{"date":"2021-12-03","current":-6.131767,"twenty":-43.823694,"median":20.173015,"eighty":74.030875,"marketCap":3726532295},{"date":"2021-12-10","current":-6.847411,"twenty":-43.823694,"median":20.114106,"eighty":72.607318,"marketCap":4161459142},{"date":"2021-12-17","current":-7.542143,"twenty":-43.823694,"median":20.025743,"eighty":70.436541,"marketCap":4583677086},{"date":"2021-12-23","current":-7.600231,"twenty":-43.823694,"median":19.891562,"eighty":60.214071,"marketCap":4618979590},{"date":"2021-12-31","current":-7.070469,"twenty":-43.823694,"median":19.796653,"eighty":53.012098,"marketCap":4297020756},{"date":"2022-01-07","current":-7.058851,"twenty":-43.611673,"median":19.749198,"eighty":51.923862,"marketCap":4289960255},{"date":"2022-01-14","current":-7.686201,"twenty":-43.611673,"median":19.64938,"eighty":51.147099,"marketCap":4671227296},{"date":"2022-01-21","current":-6.942675,"twenty":-43.611673,"median":19.61175,"eighty":50.934296,"marketCap":4219355248},{"date":"2022-01-28","current":-7.360909,"twenty":-43.611673,"median":19.468798,"eighty":50.847883,"marketCap":4473533275},{"date":"2022-02-04","current":-7.319085,"twenty":-43.611673,"median":19.28882,"eighty":50.5876,"marketCap":4448115472},{"date":"2022-02-11","current":-7.639731,"twenty":-43.611673,"median":19.164904,"eighty":50.143461,"marketCap":4642985293},{"date":"2022-02-18","current":-7.497996,"twenty":-43.611673,"median":18.965356,"eighty":49.908881,"marketCap":4556847184},{"date":"2022-02-25","current":-157.459445,"twenty":-44.533501,"median":18.77393,"eighty":49.713145,"marketCap":4502867744},{"date":"2022-03-04","current":-160.035874,"twenty":-45.829592,"median":18.155386,"eighty":49.32903,"marketCap":4576545882},{"date":"2022-03-11","current":-159.49086,"twenty":-46.633425,"median":-6.144547,"eighty":48.69515,"marketCap":4560960122},{"date":"2022-03-18","current":-174.652153,"twenty":-47.12015,"median":-6.881102,"eighty":48.427938,"marketCap":4994527626},{"date":"2022-03-25","current":-181.687786,"twenty":-47.927671,"median":-7.000763,"eighty":48.265452,"marketCap":5195725619},{"date":"2022-04-01","current":-192.736702,"twenty":-48.230031,"median":-7.040263,"eighty":47.833218,"marketCap":5511691480},{"date":"2022-04-08","current":-198.781401,"twenty":-48.689101,"median":-7.082087,"eighty":47.228668,"marketCap":5684551727},{"date":"2022-04-14","current":-202.992871,"twenty":-49.716018,"median":-7.119262,"eighty":46.918857,"marketCap":5804987145},{"date":"2022-04-22","current":-206.852389,"twenty":-50.435043,"median":-7.237762,"eighty":46.570634,"marketCap":5915357781},{"date":"2022-04-29","current":-182.216483,"twenty":-51.591015,"median":-7.300497,"eighty":46.245658,"marketCap":5210844764},{"date":"2022-05-06","current":-1322.183946,"twenty":-128.214398,"median":-7.341159,"eighty":45.925265,"marketCap":5147262100},{"date":"2022-05-13","current":-1314.170709,"twenty":-130.326929,"median":-7.37485,"eighty":45.90793,"marketCap":5116066572},{"date":"2022-05-20","current":-1438.375868,"twenty":-130.86667,"median":-7.37485,"eighty":45.90793,"marketCap":5599597254},{"date":"2022-05-27","current":-1370.6276,"twenty":-132.625178,"median":-7.37485,"eighty":45.90793,"marketCap":5335853246},{"date":"2022-06-03","current":-1316.720376,"twenty":-134.128325,"median":-7.37485,"eighty":45.90793,"marketCap":5125992422},{"date":"2022-06-10","current":-1266.091293,"twenty":-137.45382,"median":-7.37485,"eighty":45.90793,"marketCap":4928893405},{"date":"2022-06-17","current":-1284.303193,"twenty":-139.005646,"median":-7.37485,"eighty":45.90793,"marketCap":4999792332},{"date":"2022-06-24","current":-1429.634156,"twenty":-139.862338,"median":-7.360909,"eighty":45.909339,"marketCap":5565565769},{"date":"2022-07-01","current":-1386.289834,"twenty":-141.353878,"median":-7.360909,"eighty":45.909339,"marketCap":5396826323},{"date":"2022-07-08","current":-1353.144176,"twenty":-142.456573,"median":-7.360909,"eighty":45.909339,"marketCap":5267790276},{"date":"2022-07-15","current":-1431.819584,"twenty":-143.808127,"median":-7.360909,"eighty":45.909339,"marketCap":5574073640},{"date":"2022-07-22","current":-1387.746786,"twenty":-144.656772,"median":-7.360909,"eighty":45.909339,"marketCap":5402498237},{"date":"2022-07-29","current":-1368.077934,"twenty":-146.022974,"median":-7.360909,"eighty":45.909339,"marketCap":5325927396},{"date":"2022-08-05","current":-1664.567667,"twenty":-147.819198,"median":-7.360909,"eighty":45.909339,"marketCap":6480161927},{"date":"2022-08-12","current":-222.342663,"twenty":-148.698169,"median":-7.360909,"eighty":45.909339,"marketCap":6259613005},{"date":"2022-08-19","current":-221.838485,"twenty":-149.407406,"median":-7.360909,"eighty":45.909339,"marketCap":6245418872},{"date":"2022-08-26","current":-213.519542,"twenty":-149.883165,"median":-7.360909,"eighty":45.909339,"marketCap":6011215664},{"date":"2022-09-02","current":-218.006729,"twenty":-150.165357,"median":-7.360909,"eighty":45.909339,"marketCap":6137543455},{"date":"2022-09-09","current":-236.157151,"twenty":-151.092649,"median":-7.360909,"eighty":45.909339,"marketCap":6648532271},{"date":"2022-09-16","current":-233.585841,"twenty":-153.529951,"median":-7.360909,"eighty":45.909339,"marketCap":6576142189},{"date":"2022-09-23","current":-217.956312,"twenty":-156.46647,"median":-7.360909,"eighty":45.909339,"marketCap":6136124041},{"date":"2022-09-30","current":-222.998095,"twenty":-157.969129,"median":-7.360909,"eighty":45.909339,"marketCap":6278065379},{"date":"2022-10-07","current":-231.569128,"twenty":-159.577078,"median":-7.360909,"eighty":45.909339,"marketCap":6519365654},{"date":"2022-10-14","current":-233.737095,"twenty":-160.082841,"median":-7.360909,"eighty":45.909339,"marketCap":6580400429},{"date":"2022-10-21","current":-226.62818,"twenty":-160.43291,"median":-7.360909,"eighty":45.909339,"marketCap":6380263143},{"date":"2022-10-28","current":-224.913973,"twenty":-161.94987,"median":-7.360909,"eighty":45.909339,"marketCap":6332003088},{"date":"2022-11-04","current":-209.486115,"twenty":-162.370971,"median":-7.360909,"eighty":45.909339,"marketCap":5897662593},{"date":"2022-11-11","current":839.185498,"twenty":-162.756411,"median":-7.319085,"eighty":46.031035,"marketCap":6143677032},{"date":"2022-11-18","current":836.080997,"twenty":-162.756411,"median":-7.284232,"eighty":46.34415,"marketCap":6120948978},{"date":"2022-11-25","current":806.394204,"twenty":-162.756411,"median":-7.219174,"eighty":46.64061,"marketCap":5903611964},{"date":"2022-12-02","current":782.334319,"twenty":-162.756411,"median":-7.102998,"eighty":47.141347,"marketCap":5727469547},{"date":"2022-12-09","current":727.617484,"twenty":-162.756411,"median":-7.058851,"eighty":47.387939,"marketCap":5326887600},{"date":"2022-12-16","current":750.125118,"twenty":-162.756411,"median":-7.014704,"eighty":48.047842,"marketCap":5491665989},{"date":"2022-12-23","current":740.423552,"twenty":-162.756411,"median":-6.972881,"eighty":48.293594,"marketCap":5420640821},{"date":"2022-12-30","current":732.85633,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5365241190},{"date":"2023-01-06","current":786.214945,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5755879614},{"date":"2023-01-13","current":773.214846,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5660705889},{"date":"2023-01-20","current":790.871697,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5789971695},{"date":"2023-01-27","current":776.513379,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5684854446},{"date":"2023-02-03","current":793.976198,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5812699749},{"date":"2023-02-10","current":756.722183,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5539963104},{"date":"2023-02-17","current":748.96093,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5483142969},{"date":"2023-02-24","current":-18.915876,"twenty":-162.756411,"median":-6.942675,"eighty":48.318169,"marketCap":5102028010},{"date":"2023-03-03","current":-19.398181,"twenty":-162.756411,"median":-7.010057,"eighty":48.167441,"marketCap":5232116143},{"date":"2023-03-10","current":-17.998968,"twenty":-162.756411,"median":-7.047233,"eighty":47.522459,"marketCap":4854717602},{"date":"2023-03-17","current":-18.645574,"twenty":-162.756411,"median":-7.096027,"eighty":47.151665,"marketCap":5029121473},{"date":"2023-03-24","current":-17.993668,"twenty":-162.756411,"median":-7.188968,"eighty":46.719576,"marketCap":4853288062},{"date":"2023-03-31","current":-18.942377,"twenty":-162.739653,"median":-7.283071,"eighty":46.447558,"marketCap":5109175709},{"date":"2023-04-06","current":-19.392881,"twenty":-162.739653,"median":-7.309791,"eighty":46.139197,"marketCap":5230686603},{"date":"2023-04-14","current":-19.906986,"twenty":-162.756411,"median":-7.388791,"eighty":45.881909,"marketCap":5369351977},{"date":"2023-04-21","current":-19.158378,"twenty":-162.756411,"median":-7.484055,"eighty":45.586713,"marketCap":5167435947},{"date":"2023-04-28","current":-18.691747,"twenty":-162.756411,"median":-7.542143,"eighty":45.238708,"marketCap":5041575343},{"date":"2023-05-05","current":-15.654507,"twenty":-162.722895,"median":-7.581643,"eighty":45.096531,"marketCap":5148454369},{"date":"2023-05-12","current":-15.484823,"twenty":-162.005118,"median":-7.581643,"eighty":45.096531,"marketCap":5092648444},{"date":"2023-05-19","current":-15.937315,"twenty":-160.611822,"median":-7.581643,"eighty":45.096531,"marketCap":5241464245},{"date":"2023-05-26","current":-17.042442,"twenty":-160.205418,"median":-7.581643,"eighty":45.096531,"marketCap":5604918222},{"date":"2023-06-02","current":-18.682728,"twenty":-159.773437,"median":-7.581643,"eighty":45.096531,"marketCap":6144375503},{"date":"2023-06-09","current":-18.121463,"twenty":-159.192484,"median":-7.581643,"eighty":45.096531,"marketCap":5959786673},{"date":"2023-06-16","current":-18.138866,"twenty":-156.985977,"median":-7.581643,"eighty":45.096531,"marketCap":5965510357},{"date":"2023-06-23","current":-17.925673,"twenty":-155.435521,"median":-7.578157,"eighty":45.109315,"marketCap":5895395220},{"date":"2023-06-30","current":-17.886515,"twenty":-151.740635,"median":-7.574672,"eighty":45.122099,"marketCap":5882516929},{"date":"2023-07-07","current":-18.169323,"twenty":-150.657265,"median":-7.574672,"eighty":45.122099,"marketCap":5975526805},{"date":"2023-07-14","current":-18.560903,"twenty":-150.083568,"median":-7.574672,"eighty":45.122099,"marketCap":6104309711},{"date":"2023-07-21","current":-17.821251,"twenty":-149.641501,"median":-7.574672,"eighty":45.122099,"marketCap":5861053112},{"date":"2023-07-28","current":-16.750932,"twenty":-149.090615,"median":-7.574672,"eighty":45.122099,"marketCap":5509046504},{"date":"2023-08-04","current":-17.151214,"twenty":-148.303568,"median":-7.574672,"eighty":45.122099,"marketCap":5640691252},{"date":"2023-08-11","current":-18.467972,"twenty":-148.00823,"median":-7.574672,"eighty":45.122099,"marketCap":5707249602},{"date":"2023-08-18","current":-18.147959,"twenty":-147.735407,"median":-7.574672,"eighty":45.122099,"marketCap":5608354519},{"date":"2023-08-25","current":-18.463334,"twenty":-145.579013,"median":-7.574672,"eighty":45.122099,"marketCap":5705816340},{"date":"2023-09-01","current":-18.676675,"twenty":-145.219114,"median":-7.574672,"eighty":45.122099,"marketCap":5771746396},{"date":"2023-09-08","current":-18.727692,"twenty":-145.219114,"median":-7.574672,"eighty":45.122099,"marketCap":5787512279},{"date":"2023-09-15","current":-20.239635,"twenty":-145.219114,"median":-7.574672,"eighty":45.122099,"marketCap":6254755717},{"date":"2023-09-22","current":-19.701643,"twenty":-144.797122,"median":-7.574672,"eighty":45.122099,"marketCap":6088497315},{"date":"2023-09-29","current":-21.454756,"twenty":-143.400598,"median":-7.574672,"eighty":45.122099,"marketCap":6630270382},{"date":"2023-10-06","current":-21.728389,"twenty":-143.032342,"median":-7.574672,"eighty":45.122099,"marketCap":6714832844},{"date":"2023-10-13","current":-21.38055,"twenty":-143.032342,"median":-7.574672,"eighty":45.122099,"marketCap":6607338188},{"date":"2023-10-20","current":-21.593891,"twenty":-143.032342,"median":-7.574672,"eighty":45.122099,"marketCap":6673268244},{"date":"2023-10-27","current":-21.16257,"twenty":-143.300049,"median":-7.55957,"eighty":45.146419,"marketCap":6539974871},{"date":"2023-11-03","current":-15.297336,"twenty":-140.032184,"median":-7.55957,"eighty":45.146419,"marketCap":6267655075},{"date":"2023-11-10","current":-16.577399,"twenty":-22.395314,"median":-7.55957,"eighty":45.146419,"marketCap":6787665949},{"date":"2023-11-17","current":-17.008391,"twenty":-21.672735,"median":-7.55957,"eighty":45.146419,"marketCap":6964136656},{"date":"2023-11-24","current":-17.460406,"twenty":-21.484438,"median":-7.55957,"eighty":45.146419,"marketCap":7149215689},{"date":"2023-12-01","current":-17.334262,"twenty":-21.2275,"median":-7.55957,"eighty":45.146419,"marketCap":7097565726},{"date":"2023-12-08","current":-17.334262,"twenty":-20.411236,"median":-7.572349,"eighty":45.140651,"marketCap":7097565726},{"date":"2023-12-15","current":-17.456902,"twenty":-20.127399,"median":-7.572349,"eighty":45.140651,"marketCap":7147780968},{"date":"2023-12-22","current":-17.208119,"twenty":-19.907658,"median":-7.572349,"eighty":45.140651,"marketCap":7045915764},{"date":"2023-12-29","current":-17.695174,"twenty":-19.76602,"median":-7.55957,"eighty":45.146419,"marketCap":7245342009},{"date":"2024-01-05","current":-18.038565,"twenty":-19.665059,"median":-7.54679,"eighty":45.152187,"marketCap":7385944686},{"date":"2024-01-12","current":-18.763892,"twenty":-19.458602,"median":-7.54679,"eighty":45.152187,"marketCap":7682931972},{"date":"2024-01-19","current":-17.747734,"twenty":-19.2678,"median":-7.544467,"eighty":45.157955,"marketCap":7266862827},{"date":"2024-01-26","current":-18.073605,"twenty":-19.134896,"median":-7.54679,"eighty":45.152187,"marketCap":7400291898},{"date":"2024-02-02","current":-17.859862,"twenty":-19.007278,"median":-7.54679,"eighty":45.152187,"marketCap":7312773905},{"date":"2024-02-09","current":-17.512966,"twenty":-18.941814,"median":-7.54679,"eighty":45.152187,"marketCap":7170736507},{"date":"2024-02-16","current":-15.866089,"twenty":-18.881956,"median":-7.54679,"eighty":45.152187,"marketCap":6496417548},{"date":"2024-02-23","current":-17.500434,"twenty":-18.811317,"median":-7.54679,"eighty":45.152187,"marketCap":6410164032},{"date":"2024-03-01","current":-17.989873,"twenty":-18.791838,"median":-7.578157,"eighty":45.146419,"marketCap":6589438742},{"date":"2024-03-08","current":-17.774998,"twenty":-18.791838,"median":-7.603716,"eighty":45.146419,"marketCap":6510732771},{"date":"2024-03-15","current":-16.784182,"twenty":-18.791838,"median":-7.673842,"eighty":45.146419,"marketCap":6147810797},{"date":"2024-03-22","current":-17.010995,"twenty":-18.791838,"median":-7.777023,"eighty":45.146419,"marketCap":6230889321},{"date":"2024-03-28","current":-17.771018,"twenty":-18.791838,"median":-7.81825,"eighty":45.146419,"marketCap":6509275254},{"date":"2024-04-05","current":-17.042828,"twenty":-18.796083,"median":-7.904612,"eighty":45.152187,"marketCap":6242549465},{"date":"2024-04-12","current":-16.911516,"twenty":-18.796083,"median":-8.182691,"eighty":45.152187,"marketCap":6194451372},{"date":"2024-04-19","current":-16.239034,"twenty":-18.796083,"median":-8.560117,"eighty":45.152187,"marketCap":5948130835},{"date":"2024-04-26","current":-16.659633,"twenty":-18.791838,"median":-8.646128,"eighty":45.146419,"marketCap":6102190447},{"date":"2024-05-03","current":-17.157352,"twenty":-18.791838,"median":-8.845112,"eighty":45.146419,"marketCap":6284497762},{"date":"2024-05-10","current":-14.961134,"twenty":-18.791838,"median":-9.293144,"eighty":45.146419,"marketCap":5756535778},{"date":"2024-05-17","current":-14.25989,"twenty":-18.791838,"median":-9.334225,"eighty":45.146419,"marketCap":5486720952},{"date":"2024-05-24","current":-14.40393,"twenty":-18.791838,"median":-9.552464,"eighty":45.146419,"marketCap":5542142376},{"date":"2024-05-31","current":-13.854306,"twenty":-18.791838,"median":-9.739892,"eighty":45.146419,"marketCap":5330665890},{"date":"2024-06-07","current":-15.112755,"twenty":-18.791838,"median":-9.90935,"eighty":45.146419,"marketCap":5814874119},{"date":"2024-06-14","current":-15.586568,"twenty":-18.796083,"median":-9.987659,"eighty":45.152187,"marketCap":5997181434},{"date":"2024-06-21","current":-15.469062,"twenty":-18.800329,"median":-10.068299,"eighty":45.157955,"marketCap":5951969220},{"date":"2024-06-28","current":-17.902568,"twenty":-18.809069,"median":-10.099656,"eighty":45.171414,"marketCap":6888299589},{"date":"2024-07-05","current":-17.284716,"twenty":-18.809069,"median":-10.146845,"eighty":45.171414,"marketCap":6650570851},{"date":"2024-07-12","current":-17.932892,"twenty":-18.809069,"median":-10.187925,"eighty":45.171414,"marketCap":6899967258},{"date":"2024-07-15","current":-18.194437,"twenty":-18.809069,"median":-10.208466,"eighty":45.171414,"marketCap":7000600896},{"date":"2024-08-02","current":-20.490271,"twenty":-18.868176,"median":-10.389456,"eighty":45.307924,"marketCap":7484809124},{"date":"2024-08-09","current":-18.992918,"twenty":-18.884076,"median":-10.451704,"eighty":45.307924,"marketCap":6946488933},{"date":"2024-08-16","current":-18.655115,"twenty":-18.884076,"median":-10.488762,"eighty":45.307924,"marketCap":6822940561},{"date":"2024-08-23","current":-19.004911,"twenty":-18.92096,"median":-10.554325,"eighty":45.307924,"marketCap":6950875266},{"date":"2024-08-30","current":-19.948361,"twenty":-18.942377,"median":-10.636992,"eighty":45.307924,"marketCap":7295933440},{"date":"2024-09-06","current":-19.248769,"twenty":-18.979477,"median":-10.675476,"eighty":45.307924,"marketCap":7040064031},{"date":"2024-09-13","current":-17.667381,"twenty":-18.992918,"median":-10.762419,"eighty":45.307924,"marketCap":6461685590},{"date":"2024-09-20","current":-18.408188,"twenty":-18.992918,"median":-10.826557,"eighty":45.307924,"marketCap":6732629014},{"date":"2024-09-27","current":-17.701837,"twenty":-18.992918,"median":-11.068858,"eighty":45.307924,"marketCap":6474287610},{"date":"2024-10-04","current":-16.284829,"twenty":-18.992918,"median":-11.242743,"eighty":45.307924,"marketCap":5956029551},{"date":"2024-10-11","current":-16.345127,"twenty":-18.992918,"median":-12.040191,"eighty":45.307924,"marketCap":5978083085},{"date":"2024-10-18","current":-16.577706,"twenty":-18.992918,"median":-13.03948,"eighty":45.307924,"marketCap":6063146718},{"date":"2024-10-25","current":-16.698302,"twenty":-18.992918,"median":-13.446915,"eighty":45.307924,"marketCap":6107253787},{"date":"2024-10-31","current":-16.909346,"twenty":-18.992918,"median":-13.562755,"eighty":45.307924,"marketCap":6184441157},{"date":"2024-11-08","current":-16.902216,"twenty":-18.995317,"median":-13.748329,"eighty":45.31946,"marketCap":6072729658},{"date":"2024-11-15","current":-16.383322,"twenty":-18.995317,"median":-13.840323,"eighty":45.31946,"marketCap":5878515995},{"date":"2024-11-22","current":-14.935534,"twenty":-18.995317,"median":-14.176174,"eighty":45.31946,"marketCap":5359033920},{"date":"2024-11-29","current":-15.723236,"twenty":-18.995317,"median":-14.25989,"eighty":45.31946,"marketCap":5641670064},{"date":"2024-12-06","current":-16.172094,"twenty":-18.995317,"median":-14.506273,"eighty":45.31946,"marketCap":5802725297},{"date":"2024-12-13","current":-16.286509,"twenty":-18.995317,"median":-14.813304,"eighty":45.31946,"marketCap":5843778591},{"date":"2024-12-20","current":-15.661628,"twenty":-18.995317,"median":-14.935534,"eighty":45.31946,"marketCap":5619564444},{"date":"2024-12-27","current":-15.98727,"twenty":-18.995317,"median":-15.08243,"eighty":45.31946,"marketCap":5736408436},{"date":"2025-01-03","current":-15.265577,"twenty":-18.995317,"median":-15.112755,"eighty":45.31946,"marketCap":5477456886},{"date":"2025-01-10","current":-15.005943,"twenty":-18.997715,"median":-15.244128,"eighty":45.330996,"marketCap":5384297486},{"date":"2025-01-17","current":-14.205039,"twenty":-18.997715,"median":-15.281457,"eighty":45.330996,"marketCap":5096924424},{"date":"2025-01-24","current":-15.164364,"twenty":-18.997715,"median":-15.281457,"eighty":45.330996,"marketCap":5441140510},{"date":"2025-01-31","current":-14.662699,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":5261137602},{"date":"2025-02-07","current":-14.359059,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":5152188474},{"date":"2025-02-14","current":-13.35573,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":4792182660},{"date":"2025-02-21","current":-11.446164,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":5196558396},{"date":"2025-02-28","current":-10.979464,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":4983545602},{"date":"2025-03-07","current":-12.044139,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":5466798509},{"date":"2025-03-14","current":-11.522308,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":5229940998},{"date":"2025-03-21","current":-11.46277,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":5202916987},{"date":"2025-03-28","current":-11.109046,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":5042362567},{"date":"2025-04-04","current":-9.988335,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":4533675297},{"date":"2025-04-11","current":-9.354433,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":4245949060},{"date":"2025-04-17","current":-9.928797,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":4506651286},{"date":"2025-04-25","current":-10.356068,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":4700588308},{"date":"2025-05-02","current":-11.018739,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":5046935029},{"date":"2025-05-09","current":-11.380123,"twenty":-19.000114,"median":-15.297336,"eighty":45.26178,"marketCap":5212460492},{"date":"2025-05-16","current":-11.463519,"twenty":-19.000114,"median":-15.297336,"eighty":45.175259,"marketCap":5250658676},{"date":"2025-05-23","current":-11.55734,"twenty":-19.000114,"median":-15.297336,"eighty":45.175259,"marketCap":5293631632},{"date":"2025-05-30","current":-11.626837,"twenty":-19.000114,"median":-15.297336,"eighty":45.007986,"marketCap":5325463452},{"date":"2025-06-06","current":-12.24536,"twenty":-19.000114,"median":-15.297336,"eighty":44.117786,"marketCap":5608766648},{"date":"2025-06-13","current":-12.377404,"twenty":-19.000114,"median":-15.297336,"eighty":-6.098308,"marketCap":5669247106},{"date":"2025-06-20","current":-12.860408,"twenty":-19.002512,"median":-15.301886,"eighty":-6.769341,"marketCap":5890478253},{"date":"2025-06-27","current":-13.82294,"twenty":-19.002512,"median":-15.301886,"eighty":-6.989146,"marketCap":6331348958},{"date":"2025-07-03","current":-14.941841,"twenty":-19.002512,"median":-15.301886,"eighty":-7.017492,"marketCap":6843841257},{"date":"2025-07-11","current":-14.7264,"twenty":-19.002512,"median":-15.301886,"eighty":-7.061175,"marketCap":6745162615},{"date":"2025-07-18","current":-14.653429,"twenty":-19.002512,"median":-15.301886,"eighty":-7.105786,"marketCap":6711739204},{"date":"2025-07-25","current":-14.646479,"twenty":-19.002512,"median":-15.301886,"eighty":-7.221033,"marketCap":6708556022},{"date":"2025-08-01","current":-25.541485,"twenty":-19.026904,"median":-15.342587,"eighty":-7.288415,"marketCap":6850635022},{"date":"2025-08-08","current":-24.394555,"twenty":-19.059439,"median":-15.406519,"eighty":-7.31955,"marketCap":6543009950},{"date":"2025-08-15","current":-25.464231,"twenty":-19.208439,"median":-15.476942,"eighty":-7.439444,"marketCap":6829914162},{"date":"2025-08-22","current":-25.693023,"twenty":-19.327123,"median":-15.573133,"eighty":-7.500784,"marketCap":6891279785},{"date":"2025-08-29","current":-25.32755,"twenty":-19.462842,"median":-15.656683,"eighty":-7.572814,"marketCap":6793254179},{"date":"2025-09-05","current":-35.269594,"twenty":-19.610183,"median":-15.723236,"eighty":-7.595584,"marketCap":9459869441},{"date":"2025-09-12","current":-38.056694,"twenty":-19.731561,"median":-15.763036,"eighty":-7.642541,"marketCap":10207414305},{"date":"2025-09-19","current":-36.689886,"twenty":-19.905803,"median":-15.876073,"eighty":-7.741966,"marketCap":9840814478},{"date":"2025-09-26","current":-37.420831,"twenty":-20.021346,"median":-16.03996,"eighty":-7.801291,"marketCap":10036865690},{"date":"2025-10-03","current":-40.647687,"twenty":-20.250766,"median":-16.203648,"eighty":-7.855354,"marketCap":10902360063},{"date":"2025-10-10","current":-41.758962,"twenty":-20.936243,"median":-16.267488,"eighty":-8.057965,"marketCap":11200421661},{"date":"2025-10-17","current":-43.422902,"twenty":-21.44548,"median":-16.302057,"eighty":-8.466659,"marketCap":11646717103},{"date":"2025-10-24","current":-42.489907,"twenty":-21.627284,"median":-16.365719,"eighty":-8.619683,"marketCap":11396472873},{"date":"2025-10-31","current":-46.865674,"twenty":-22.311833,"median":-16.491552,"eighty":-8.824572,"marketCap":12013640728},{"date":"2025-11-07","current":-46.821444,"twenty":-24.565703,"median":-16.551864,"eighty":-9.220997,"marketCap":12002302521},{"date":"2025-11-14","current":-44.129685,"twenty":-25.310911,"median":-16.577552,"eighty":-9.310347,"marketCap":11312291607},{"date":"2025-11-21","current":-46.202213,"twenty":-25.459477,"median":-16.623152,"eighty":-9.406991,"marketCap":11843567616},{"date":"2025-11-28","current":-52.274467,"twenty":-25.606854,"median":-16.659586,"eighty":-9.54788,"marketCap":13400141532},{"date":"2025-12-05","current":-51.693149,"twenty":-25.977676,"median":-16.714478,"eighty":-9.709339,"marketCap":13251125091},{"date":"2025-12-12","current":-50.00606,"twenty":-36.254884,"median":-16.738094,"eighty":-9.817591,"marketCap":12818653462},{"date":"2025-12-19","current":-49.051939,"twenty":-36.458718,"median":-16.773398,"eighty":-9.930898,"marketCap":12574072128},{"date":"2025-12-26","current":-50.960181,"twenty":-37.51116,"median":-16.804783,"eighty":-9.964551,"marketCap":13063234795},{"date":"2026-01-02","current":-49.987104,"twenty":-38.080464,"median":-16.872737,"eighty":-9.994875,"marketCap":12813794230},{"date":"2026-01-09","current":-51.522544,"twenty":-40.33867,"median":-16.913584,"eighty":-10.055281,"marketCap":13207392005},{"date":"2026-01-16","current":-48.786554,"twenty":-41.579494,"median":-16.936559,"eighty":-10.101905,"marketCap":12506042883},{"date":"2026-01-23","current":-51.680511,"twenty":-42.352038,"median":-16.969214,"eighty":-10.147872,"marketCap":13247885603},{"date":"2026-01-30","current":-53.001116,"twenty":-43.304049,"median":-17.016336,"eighty":-10.177655,"marketCap":13586412084},{"date":"2026-02-06","current":-52.748369,"twenty":-43.896106,"median":-17.042828,"eighty":-10.276361,"marketCap":13521622327},{"date":"2026-02-13","current":-51.674193,"twenty":-45.89007,"median":-17.08842,"eighty":-10.365331,"marketCap":13246265859},{"date":"2026-02-20","current":-52.536693,"twenty":-46.437268,"median":-17.113581,"eighty":-10.415699,"marketCap":13467360905},{"date":"2026-02-27","current":-34.265449,"twenty":-46.808807,"median":-17.154283,"eighty":-10.419492,"marketCap":13055136075},{"date":"2026-03-06","current":-32.554417,"twenty":-46.808807,"median":-17.180856,"eighty":-10.419492,"marketCap":12415831546},{"date":"2026-03-13","current":-31.332977,"twenty":-46.808807,"median":-17.209871,"eighty":-10.419492,"marketCap":11949990075},{"date":"2026-03-20","current":-30.891179,"twenty":-46.808807,"median":-17.218631,"eighty":-10.419492,"marketCap":11781494224},{"date":"2026-03-27","current":-32.155933,"twenty":-46.808807,"median":-17.24834,"eighty":-10.419492,"marketCap":12263854896},{"date":"2026-04-02","current":-32.541423,"twenty":-46.808807,"median":-17.287579,"eighty":-10.419492,"marketCap":12410875786},{"date":"2026-04-10","current":-33.104499,"twenty":-46.808807,"median":-17.33251,"eighty":-10.419492,"marketCap":12625625400},{"date":"2026-04-17","current":-32.597731,"twenty":-46.808807,"median":-17.370954,"eighty":-10.419492,"marketCap":12432350747},{"date":"2026-04-24","current":-32.090963,"twenty":-46.808807,"median":-17.417852,"eighty":-10.419492,"marketCap":12239076094},{"date":"2026-05-01","current":-37.78562,"twenty":-46.808807,"median":-17.460406,"eighty":-10.419492,"marketCap":12355028686},{"date":"2026-05-08","current":-38.422456,"twenty":-46.808807,"median":-17.499692,"eighty":-10.425443,"marketCap":12563259507},{"date":"2026-05-15","current":-38.250612,"twenty":-46.808807,"median":-17.54086,"eighty":-10.441583,"marketCap":12507070238},{"date":"2026-05-22","current":-38.301154,"twenty":-46.808807,"median":-17.626193,"eighty":-10.45769,"marketCap":12523596493},{"date":"2026-05-29","current":-39.084564,"twenty":-46.821444,"median":-17.65446,"eighty":-10.515842,"marketCap":12779753455},{"date":"2026-06-05","current":-37.972628,"twenty":-46.808807,"median":-17.690774,"eighty":-10.584827,"marketCap":12416175832},{"date":"2026-06-12","current":-37.31052,"twenty":-46.808807,"median":-17.738974,"eighty":-10.668419,"marketCap":12199681883},{"date":"2026-06-18","current":-37.558179,"twenty":-46.808807,"median":-17.769888,"eighty":-10.69486,"marketCap":12280660536},{"date":"2026-06-26","current":-39.595044,"twenty":-46.821444,"median":-17.818766,"eighty":-10.726786,"marketCap":12946668637},{"date":"2026-07-02","current":-40.024656,"twenty":-46.821444,"median":-17.854581,"eighty":-10.726786,"marketCap":13087141809},{"date":"2026-07-10","current":-32.483705,"twenty":-46.821444,"median":-17.871767,"eighty":-10.726786,"marketCap":10621424474},{"date":"2026-07-17","current":-27.621511,"twenty":-46.821444,"median":-17.880886,"eighty":-10.979464,"marketCap":9031598685},{"date":"2026-07-24","current":-28.23813,"twenty":-46.821444,"median":-17.925673,"eighty":-11.109046,"marketCap":9233219003},{"date":"2026-07-31","current":-15.666504,"twenty":-46.83029,"median":-17.93492,"eighty":-11.257113,"marketCap":8854300676},{"date":"2026-08-07","current":-16.022293,"twenty":-46.83029,"median":-17.93492,"eighty":-11.326236,"marketCap":9055383705},{"date":"2026-08-14","current":-16.42807,"twenty":-46.83029,"median":-17.93492,"eighty":-11.457268,"marketCap":9284718070},{"date":"2026-08-21","current":-17.277849,"twenty":-46.83029,"median":-17.93492,"eighty":-11.52511,"marketCap":9764990760},{"date":"2026-08-28","current":-18.356979,"twenty":-46.83029,"median":-17.973741,"eighty":-11.565738,"marketCap":10374887222},{"date":"2026-09-04","current":-17.092603,"twenty":-46.83029,"median":-17.982683,"eighty":-11.643516,"marketCap":9660294637},{"date":"2026-09-11","current":-16.363381,"twenty":-46.83029,"median":-17.982683,"eighty":-11.688179,"marketCap":9248157519},{"date":"2026-09-14","current":-15.939962,"twenty":-46.83029,"median":-17.982683,"eighty":-11.698961,"marketCap":9008852095}],"updateTime":1789531474516},"$inf$@#url:\"https://stock-news.skytigris.cn/v3/notice/important/events/list\",params:#symbol:\"IONS\",pageSize:20,pageCount:17,market:\"us\",,,undefined,":[{"items":[{"cdn_pdf":false,"hasAttachments":true,"id":"11957842","market":"us","labels":[],"media":"sec.gov","original_id":"AN119312521041468-IONS","pdf_url":null,"pub_time":1613059200000,"showTitleType":true,"size":0,"source":"sec_us","summary":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","symbol":"IONS","title":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","titleType":"超過5%披露","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000119312521041468/0001193125-21-041468-index.htm","us_notice_code":"Form SC 13G/A","us_title_en":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"SC 13G/A","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312521041468/d129891dsc13ga.htm","primary":true,"translateUrl":null,"linkName":"d129891dsc13ga.htm","type":"SC 13G/A","id":"NTFILECupHTwR5gTVhUVAk","market":"us","size":51742}],"type_name":"交易披露","type_name_en":"Transaction Related","titleTypeEn":"Beneficial Ownership Change","us_type":"usAnnouncement","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"超過5%披露","pubTime":"2021-02-12 00:00","pubTimestamp":1613059200,"title_zh":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"11957844","market":"us","labels":[],"media":"sec.gov","original_id":"AN110465921018387-IONS","pdf_url":null,"pub_time":1612886400000,"showTitleType":true,"size":0,"source":"sec_us","summary":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","symbol":"IONS","title":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","titleType":"超過5%披露","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000110465921018387/0001104659-21-018387-index.htm","us_notice_code":"Form SC 13G/A","us_title_en":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"SCHEDULE 13G/A","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/102909/000110465921018387/tv01163-ionispharmaceuticals.htm","primary":true,"translateUrl":null,"linkName":"tv01163-ionispharmaceuticals.htm","type":"SC 13G/A","id":"NTFILEHyeL6HzMpJpYa7Xb","market":"us","size":12339}],"type_name":"交易披露","type_name_en":"Transaction Related","titleTypeEn":"Beneficial Ownership Change","us_type":"usAnnouncement","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"超過5%披露","pubTime":"2021-02-10 00:00","pubTimestamp":1612886400,"title_zh":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"11780572","market":"us","labels":[],"media":"sec.gov","original_id":"AN134888321000018-IONS","pdf_url":null,"pub_time":1612800000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","symbol":"IONS","title":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","titleType":"超過5%披露","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000134888321000018/0001348883-21-000018-index.htm","us_notice_code":"Form SC 13G/A","us_title_en":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000134888321000018/ioni20a10.htm","primary":true,"translateUrl":null,"linkName":"ioni20a10.htm","type":"SC 13G/A","id":"NTFILEEye88yVsKG6qdy8g","market":"us","size":81767}],"type_name":"交易披露","type_name_en":"Transaction Related","titleTypeEn":"Beneficial Ownership Change","us_type":"usAnnouncement","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"超過5%披露","pubTime":"2021-02-09 00:00","pubTimestamp":1612800000,"title_zh":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":false,"id":"11780567","market":"us","labels":[],"media":"sec.gov","original_id":"AN31506621001069-IONS","pdf_url":null,"pub_time":1612713600000,"showTitleType":true,"size":0,"source":"sec_us","summary":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","symbol":"IONS","title":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","titleType":"超過5%披露","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000031506621001069/0000315066-21-001069-index.htm","us_notice_code":"Form SC 13G/A","us_title_en":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[],"type_name":"交易披露","type_name_en":"Transaction Related","titleTypeEn":"Beneficial Ownership Change","us_type":"usAnnouncement","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"超過5%披露","pubTime":"2021-02-08 00:00","pubTimestamp":1612713600,"title_zh":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":false,"id":"11780579","market":"us","labels":[],"media":"sec.gov","original_id":"AN83423721007434-IONS","pdf_url":null,"pub_time":1612454400000,"showTitleType":true,"size":0,"source":"sec_us","summary":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","symbol":"IONS","title":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","titleType":"超過5%披露","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000083423721007434/0000834237-21-007434-index.htm","us_notice_code":"Form SC 13G/A","us_title_en":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[],"type_name":"交易披露","type_name_en":"Transaction Related","titleTypeEn":"Beneficial Ownership Change","us_type":"usAnnouncement","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"超過5%披露","pubTime":"2021-02-05 00:00","pubTimestamp":1612454400,"title_zh":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"11957845","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036121001189-IONS","pdf_url":null,"pub_time":1610553600000,"showTitleType":true,"size":0,"source":"sec_us","summary":"CORRESP [Cover] - Correspondence","symbol":"IONS","title":"CORRESP [Cover] - Correspondence","titleType":"SEC問詢函","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036121001189/0001140361-21-001189-index.htm","us_notice_code":"Form CORRESP","us_title_en":"CORRESP [Cover] - Correspondence","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036121001189/filename1.htm","primary":true,"translateUrl":null,"linkName":"filename1.htm","type":"CORRESP","id":"NTFILEFHvnykiqEkTFcQrH","market":"us","size":128161}],"type_name":"交易披露","type_name_en":"Transaction Related","titleTypeEn":"Correspondence","us_type":"usAnnouncement","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"SEC問詢函","pubTime":"2021-01-14 00:00","pubTimestamp":1610553600,"title_zh":"CORRESP [Cover] - Correspondence","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"11328157","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036120030055-IONS","pdf_url":null,"pub_time":1609344000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"S-8 - Securities to be offered to employees in employee benefit plans","symbol":"IONS","title":"S-8 - Securities to be offered to employees in employee benefit plans","titleType":"員工持股計劃","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036120030055/0001140361-20-030055-index.htm","us_notice_code":"Form S-8","us_title_en":"S-8 - Securities to be offered to employees in employee benefit plans","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"S-8","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120030055/brhc10018560_s8.htm","primary":true,"translateUrl":null,"linkName":"brhc10018560_s8.htm","type":"S-8","id":"NTFILE1kqo3aWZaeS49R7d","market":"us","size":67602},{"description":"EXHIBIT 5.1","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120030055/brhc10018560_ex5-1.htm","primary":false,"translateUrl":null,"linkName":"brhc10018560_ex5-1.htm","type":"EX-5.1","id":"NTFILEGwcqRLip3BPwHQGv","market":"us","size":5059},{"description":"EXHIBIT 23.1","seq":3,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120030055/brhc10018560_ex23-1.htm","primary":false,"translateUrl":null,"linkName":"brhc10018560_ex23-1.htm","type":"EX-23.1","id":"NTFILE6SG1ndqy2KiZ5UDA","market":"us","size":2902},{"description":"EXHIBIT 99.1","seq":4,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120030055/brhc10018560_ex99-1.htm","primary":false,"translateUrl":null,"linkName":"brhc10018560_ex99-1.htm","type":"EX-99.1","id":"NTFILECshz23CYn9Fa1Xjb","market":"us","size":118987},{"description":"EXHIBIT 99.2","seq":5,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120030055/brhc10018560_ex99-2.htm","primary":false,"translateUrl":null,"linkName":"brhc10018560_ex99-2.htm","type":"EX-99.2","id":"NTFILE8FU5kcoJT4Hev11M","market":"us","size":84160},{"description":"EXHIBIT 99.3","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120030055/brhc10018560_ex99-3.htm","primary":false,"translateUrl":null,"linkName":"brhc10018560_ex99-3.htm","type":"EX-99.3","id":"NTFILE3ZQeAgiZ9SVdN11a","market":"us","size":92971},{"description":"EXHIBIT 99.4","seq":7,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120030055/brhc10018560_ex99-4.htm","primary":false,"translateUrl":null,"linkName":"brhc10018560_ex99-4.htm","type":"EX-99.4","id":"NTFILE4y8zaCa3GTVFdL8D","market":"us","size":35017}],"type_name":"交易披露","type_name_en":"Transaction Related","titleTypeEn":"Employee Stock Ownership","us_type":"usAnnouncement","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"員工持股計劃","pubTime":"2020-12-31 00:00","pubTimestamp":1609344000,"title_zh":"S-8 - Securities to be offered to employees in employee benefit plans","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"11328153","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036120028770-IONS","pdf_url":null,"pub_time":1608220800000,"showTitleType":true,"size":0,"source":"sec_us","summary":"8-K - Current report","symbol":"IONS","title":"8-K - Current report","titleType":"重要事件披露","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036120028770/0001140361-20-028770-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 1.01: Entry into a Material Definitive Agreement;\nItem 5.02: Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers: Compensatory Arrangements of Certain Officers;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"EXHIBIT 99.1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120028770/brhc10018098_ex99-1.htm","primary":true,"translateUrl":null,"linkName":"brhc10018098_ex99-1.htm","type":"EX-99.1","id":"NTFILEFEwJRcqPx56qqDYh","market":"us","size":9443},{"description":"8-K","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120028770/brhc10018098_8k.htm","primary":false,"translateUrl":null,"linkName":"brhc10018098_8k.htm","type":"8-K","id":"NTFILEHG5kewdznATPkAZH","market":"us","size":26566},{"description":"","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120028770/image0.jpg","primary":false,"translateUrl":null,"linkName":"image0.jpg","type":"GRAPHIC","id":"NTFILE8YM32YqfSnhgsExc","market":"us","size":11357}],"type_name":"交易披露","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"usAnnouncement","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"重要事件披露","pubTime":"2020-12-18 00:00","pubTimestamp":1608220800,"title_zh":"8-K - Current report","summary_en":"Item 1.01: Entry into a Material Definitive Agreement;\nItem 5.02: Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers: Compensatory Arrangements of Certain Officers;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"第1.01項:訂立實質性最終協議；第5.02項:董事或某些官員離職；選舉董事；某些官員的任命:某些官員的補償安排；項目9.01:財務報表和報表","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"11100041","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036120027746-IONS","pdf_url":null,"pub_time":1607443200000,"showTitleType":true,"size":0,"source":"sec_us","summary":"8-K - Current report","symbol":"IONS","title":"8-K - Current report","titleType":"重要事件披露","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036120027746/0001140361-20-027746-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 8.01: Other Events;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"EXHIBIT 99.1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120027746/brhc10017778_ex99-1.htm","primary":true,"translateUrl":null,"linkName":"brhc10017778_ex99-1.htm","type":"EX-99.1","id":"NTFILED3D1nBeToz7pmn6V","market":"us","size":36658},{"description":"8-K","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120027746/brhc10017778_8k.htm","primary":false,"translateUrl":null,"linkName":"brhc10017778_8k.htm","type":"8-K","id":"NTFILE3Um6izhQMAzhKUA5","market":"us","size":27296},{"description":"","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120027746/image0.jpg","primary":false,"translateUrl":null,"linkName":"image0.jpg","type":"GRAPHIC","id":"NTFILEG5CXTduPTzwD3WMx","market":"us","size":11357}],"type_name":"交易披露","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"usAnnouncement","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"重要事件披露","pubTime":"2020-12-09 00:00","pubTimestamp":1607443200,"title_zh":"8-K - Current report","summary_en":"Item 8.01: Other Events;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"項目8.01:其他活動；項目9.01:財務報表和報表","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"10725268","market":"us","labels":[],"media":"sec.gov","original_id":"AN87401520000142-IONS","pdf_url":null,"pub_time":1604419200000,"showTitleType":true,"size":0,"source":"sec_us","summary":"10-Q - Quarterly report [Sections 13 or 15(d)]","symbol":"IONS","title":"10-Q - Quarterly report [Sections 13 or 15(d)]","titleType":"季度報告","type":"usFinancials","url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000142/0000874015-20-000142-index.htm","us_notice_code":"Form 10-Q","us_title_en":"10-Q - Quarterly report [Sections 13 or 15(d)]","is_important":0,"hasEarnInfos":true,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"IONIS PHARMACEUTICALS INC 10-Q 9-30-2020","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000142/form10q.htm","primary":true,"translateUrl":null,"linkName":"form10q.htm","type":"10-Q","id":"NTFILEHQ985opxzCEcLYMR","market":"us","size":2670664},{"description":"EXHIBIT 31.1","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000142/ex31_1.htm","primary":false,"translateUrl":null,"linkName":"ex31_1.htm","type":"EX-31.1","id":"NTFILEFuFMiLnVQCzJ7toF","market":"us","size":13547},{"description":"EXHIBIT 31.2","seq":3,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000142/ex31_2.htm","primary":false,"translateUrl":null,"linkName":"ex31_2.htm","type":"EX-31.2","id":"NTFILEJ6uApu6jqtqZiqDj","market":"us","size":13464},{"description":"EXHIBIT 32.1","seq":4,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000142/ex32_1.htm","primary":false,"translateUrl":null,"linkName":"ex32_1.htm","type":"EX-32.1","id":"NTFILEDVRyQzfRxs7eMGvC","market":"us","size":7023}],"type_name":"財務報告","type_name_en":"Financial Report","titleTypeEn":"Quarterly Report","us_type":"usFinancials","us_type_zh":"財務報告","earn_infos":[{"id":47944,"name":"CONDENSED CONSOLIDATED BALANCE SHEETS (Unaudited)","name_zh":null,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000142/R2.htm","cdn_url":"","translation_url":"","translate_status":0},{"id":47945,"name":"CONDENSED CONSOLIDATED BALANCE SHEETS (Unaudited) (Parenthetical)","name_zh":null,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000142/R3.htm","cdn_url":"","translation_url":"","translate_status":0},{"id":47946,"name":"CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS (Unaudited)","name_zh":null,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000142/R4.htm","cdn_url":"","translation_url":"","translate_status":0},{"id":47947,"name":"CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME (LOSS) (Unaudited)","name_zh":null,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000142/R5.htm","cdn_url":"","translation_url":"","translate_status":0},{"id":47948,"name":"CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (Unaudited)","name_zh":null,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000142/R6.htm","cdn_url":"","translation_url":"","translate_status":0},{"id":47949,"name":"CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited)","name_zh":"簡明合併現金流量表（未經審計）","url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000142/R7.htm","cdn_url":"https://static.tigerbbs.com/3b7fe9c2ff49bf26bec185b55c4a2512","translation_url":"https://static.tigerbbs.com/05d98c42fde2bed64b38fefcd3d19711","translate_status":1}],"event_type":"important_notice","event_name":"季度報告","pubTime":"2020-11-04 00:00","pubTimestamp":1604419200,"title_zh":"10-Q - Quarterly report [Sections 13 or 15(d","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"10723061","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036120024494-IONS","pdf_url":null,"pub_time":1604419200000,"showTitleType":true,"size":0,"source":"sec_us","summary":"8-K - Current report","symbol":"IONS","title":"8-K - Current report","titleType":"重要事件披露","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036120024494/0001140361-20-024494-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 2.02: Results of Operations and Financial Condition;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"EXHIBIT 99.1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120024494/brhc10016584_99-1.htm","primary":true,"translateUrl":null,"linkName":"brhc10016584_99-1.htm","type":"EX-99.1","id":"NTFILE9Rif3vrHh8BkFA7W","market":"us","size":453244},{"description":"8-K","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120024494/brhc10016584_8k.htm","primary":false,"translateUrl":null,"linkName":"brhc10016584_8k.htm","type":"8-K","id":"NTFILEG3cz2XVcNCadyHqF","market":"us","size":25088},{"description":"","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120024494/image00001.jpg","primary":false,"translateUrl":null,"linkName":"image00001.jpg","type":"GRAPHIC","id":"NTFILE5RhDZKL4gvS6dHvv","market":"us","size":4803}],"type_name":"交易披露","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"usAnnouncement","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"重要事件披露","pubTime":"2020-11-04 00:00","pubTimestamp":1604419200,"title_zh":"8-K - Current report","summary_en":"Item 2.02: Results of Operations and Financial Condition;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"第2.02項:經營成果和財務狀況；項目9.01:財務報表和報表","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"10449402","market":"us","labels":[],"media":"sec.gov","original_id":"AN119312520268022-IONS","pdf_url":null,"pub_time":1602518400000,"showTitleType":true,"size":0,"source":"sec_us","summary":"SC 13D/A [Amend] - General statement of acquisition of beneficial ownership","symbol":"IONS","title":"SC 13D/A [Amend] - General statement of acquisition of beneficial ownership","titleType":"超過5%披露","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000119312520268022/0001193125-20-268022-index.htm","us_notice_code":"Form SC 13D/A","us_title_en":"SC 13D/A [Amend] - General statement of acquisition of beneficial ownership","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"SC 13D/A","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312520268022/d21546dsc13da.htm","primary":true,"translateUrl":null,"linkName":"d21546dsc13da.htm","type":"SC 13D/A","id":"NTFILE78ehvxp2bJrVEmj8","market":"us","size":33818}],"type_name":"交易披露","type_name_en":"Transaction Related","titleTypeEn":"Beneficial Ownership Change","us_type":"usAnnouncement","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"超過5%披露","pubTime":"2020-10-13 00:00","pubTimestamp":1602518400,"title_zh":"SC 13D/A [Amend] - General statement of acquisition of beneficial ownership","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"10449394","market":"us","labels":[],"media":"sec.gov","original_id":"AN119312520268017-IONS","pdf_url":null,"pub_time":1602518400000,"showTitleType":true,"size":0,"source":"sec_us","summary":"8-K - Current report","symbol":"IONS","title":"8-K - Current report","titleType":"重要事件披露","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000119312520268017/0001193125-20-268017-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 2.01: Completion of Acquisition or Disposition of Assets;\nItem 8.01: Other Events;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"EX-99.1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312520268017/d23018dex991.htm","primary":true,"translateUrl":null,"linkName":"d23018dex991.htm","type":"EX-99.1","id":"NTFILEG2mtTjgocxZAHnzQ","market":"us","size":9891},{"description":"8-K","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312520268017/d23018d8k.htm","primary":false,"translateUrl":null,"linkName":"d23018d8k.htm","type":"8-K","id":"NTFILE46YgMeRNt6KuAduz","market":"us","size":33679},{"description":"GRAPHIC","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312520268017/g23018img1.jpg","primary":false,"translateUrl":null,"linkName":"g23018img1.jpg","type":"GRAPHIC","id":"NTFILEBXeL7rYmZvFZnTjF","market":"us","size":1774}],"type_name":"交易披露","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"usAnnouncement","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"重要事件披露","pubTime":"2020-10-13 00:00","pubTimestamp":1602518400,"title_zh":"8-K - Current report","summary_en":"Item 2.01: Completion of Acquisition or Disposition of Assets;\nItem 8.01: Other Events;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"第2.01項:完成收購或處置資產；項目8.01:其他活動；項目9.01:財務報表和報表","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"10427499","market":"us","labels":[],"media":"sec.gov","original_id":"AN108887520000089-IONS","pdf_url":null,"pub_time":1601568000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","symbol":"IONS","title":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","titleType":"超過5%披露","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000108887520000089/0001088875-20-000089-index.htm","us_notice_code":"Form SC 13G/A","us_title_en":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000108887520000089/ionispharmaceuticals300920.txt","primary":true,"translateUrl":null,"linkName":"ionispharmaceuticals300920.txt","type":"SC 13G/A","id":"NTFILE8NuNoqFti6wTLqXJ","market":"us","size":9733}],"type_name":"交易披露","type_name_en":"Transaction Related","titleTypeEn":"Beneficial Ownership Change","us_type":"usAnnouncement","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"超過5%披露","pubTime":"2020-10-02 00:00","pubTimestamp":1601568000,"title_zh":"SC 13G/A [Amend] - Statement of acquisition of beneficial ownership by individuals","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"11100034","market":"us","labels":[],"media":"sec.gov","original_id":"AN119312520253516-IONS","pdf_url":null,"pub_time":1600876800000,"showTitleType":true,"size":0,"source":"sec_us","summary":"CORRESP [Cover] - Correspondence","symbol":"IONS","title":"CORRESP [Cover] - Correspondence","titleType":"SEC問詢函","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000119312520253516/0001193125-20-253516-index.htm","us_notice_code":"Form CORRESP","us_title_en":"CORRESP [Cover] - Correspondence","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312520253516/filename1.htm","primary":true,"translateUrl":null,"linkName":"filename1.htm","type":"CORRESP","id":"NTFILE4qwHRGr1C2CRNF21","market":"us","size":34022}],"type_name":"交易披露","type_name_en":"Transaction Related","titleTypeEn":"Correspondence","us_type":"usAnnouncement","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"SEC問詢函","pubTime":"2020-09-24 00:00","pubTimestamp":1600876800,"title_zh":"CORRESP [Cover] - Correspondence","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"10322557","market":"us","labels":[],"media":"sec.gov","original_id":"AN119312520235414-IONS","pdf_url":null,"pub_time":1598803200000,"showTitleType":true,"size":0,"source":"sec_us","summary":"SC 13D/A [Amend] - General statement of acquisition of beneficial ownership","symbol":"IONS","title":"SC 13D/A [Amend] - General statement of acquisition of beneficial ownership","titleType":"超過5%披露","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000119312520235414/0001193125-20-235414-index.htm","us_notice_code":"Form SC 13D/A","us_title_en":"SC 13D/A [Amend] - General statement of acquisition of beneficial ownership","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"SC 13D/A","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312520235414/d30784dsc13da.htm","primary":true,"translateUrl":null,"linkName":"d30784dsc13da.htm","type":"SC 13D/A","id":"NTFILE55hTuuiEgr9qwJ97","market":"us","size":40647}],"type_name":"交易披露","type_name_en":"Transaction Related","titleTypeEn":"Beneficial Ownership Change","us_type":"usAnnouncement","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"超過5%披露","pubTime":"2020-08-31 00:00","pubTimestamp":1598803200,"title_zh":"SC 13D/A [Amend] - General statement of acquisition of beneficial ownership","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"10322520","market":"us","labels":[],"media":"sec.gov","original_id":"AN119312520235408-IONS","pdf_url":null,"pub_time":1598803200000,"showTitleType":true,"size":0,"source":"sec_us","summary":"8-K - Current report","symbol":"IONS","title":"8-K - Current report","titleType":"重要事件披露","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000119312520235408/0001193125-20-235408-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 1.01: Entry into a Material Definitive Agreement;\nItem 8.01: Other Events;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"EX-2.1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312520235408/d75253dex21.htm","primary":true,"translateUrl":null,"linkName":"d75253dex21.htm","type":"EX-2.1","id":"NTFILEHRsQ5UBvjpLdygbx","market":"us","size":432502},{"description":"8-K","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312520235408/d75253d8k.htm","primary":false,"translateUrl":null,"linkName":"d75253d8k.htm","type":"8-K","id":"NTFILEDcirVTobU5XKN9y6","market":"us","size":42020},{"description":"EX-99.1","seq":3,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312520235408/d75253dex991.htm","primary":false,"translateUrl":null,"linkName":"d75253dex991.htm","type":"EX-99.1","id":"NTFILEAFPi3skPSrNybLMz","market":"us","size":22971},{"description":"XBRL TAXONOMY EXTENSION SCHEMA","seq":4,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312520235408/ions-20200830.xsd","primary":false,"translateUrl":null,"linkName":"ions-20200830.xsd","type":"EX-101.SCH","id":"NTFILED5BihsgHi6PxgHPg","market":"us","size":3060},{"description":"XBRL TAXONOMY EXTENSION LABEL LINKBASE","seq":5,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312520235408/ions-20200830_lab.xml","primary":false,"translateUrl":null,"linkName":"ions-20200830_lab.xml","type":"EX-101.LAB","id":"NTFILE9cGVC2aQouo7SnaX","market":"us","size":17373},{"description":"XBRL TAXONOMY EXTENSION PRESENTATION LINKBASE","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312520235408/ions-20200830_pre.xml","primary":false,"translateUrl":null,"linkName":"ions-20200830_pre.xml","type":"EX-101.PRE","id":"NTFILE57rjwEWWc48sNADB","market":"us","size":10946},{"description":"EXTRACTED XBRL INSTANCE DOCUMENT","seq":7,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312520235408/d75253d8k_htm.xml","primary":false,"translateUrl":null,"linkName":"d75253d8k_htm.xml","type":"XML","id":"NTFILE3zcQDnVV3X8Jnu6M","market":"us","size":3272}],"type_name":"交易披露","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"usAnnouncement","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"重要事件披露","pubTime":"2020-08-31 00:00","pubTimestamp":1598803200,"title_zh":"8-K - Current report","summary_en":"Item 1.01: Entry into a Material Definitive Agreement;\nItem 8.01: Other Events;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"第1.01項:訂立實質性最終協議；項目8.01:其他活動；項目9.01:財務報表和報表","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"10240333","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036120017841-IONS","pdf_url":null,"pub_time":1596988800000,"showTitleType":true,"size":0,"source":"sec_us","summary":"S-8 - Securities to be offered to employees in employee benefit plans","symbol":"IONS","title":"S-8 - Securities to be offered to employees in employee benefit plans","titleType":"員工持股計劃","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036120017841/0001140361-20-017841-index.htm","us_notice_code":"Form S-8","us_title_en":"S-8 - Securities to be offered to employees in employee benefit plans","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"S-8","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120017841/nt10014191x2_s8.htm","primary":true,"translateUrl":null,"linkName":"nt10014191x2_s8.htm","type":"S-8","id":"NTFILEDHzBb94diRUBr5aU","market":"us","size":69196},{"description":"EXHIBIT 5.1","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120017841/nt10014191x2_ex5-1.htm","primary":false,"translateUrl":null,"linkName":"nt10014191x2_ex5-1.htm","type":"EX-5.1","id":"NTFILE28URoTNPKUJeSJAS","market":"us","size":7187},{"description":"EXHIBIT 23.1","seq":3,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120017841/nt10014191x2_ex23-1.htm","primary":false,"translateUrl":null,"linkName":"nt10014191x2_ex23-1.htm","type":"EX-23.1","id":"NTFILE59j7PhAG138qsc26","market":"us","size":3122},{"description":"EXHIBIT 99.2","seq":4,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120017841/nt10014191x2_ex99-2.htm","primary":false,"translateUrl":null,"linkName":"nt10014191x2_ex99-2.htm","type":"EX-99.2","id":"NTFILEH2PJbDYCkcNXxQYN","market":"us","size":38021},{"description":"EXHIBIT 99.3","seq":5,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120017841/nt10014191x2_ex99-3.htm","primary":false,"translateUrl":null,"linkName":"nt10014191x2_ex99-3.htm","type":"EX-99.3","id":"NTFILE8cvmhEdjhf6WjWbP","market":"us","size":54883}],"type_name":"交易披露","type_name_en":"Transaction Related","titleTypeEn":"Employee Stock Ownership","us_type":"usAnnouncement","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"員工持股計劃","pubTime":"2020-08-10 00:00","pubTimestamp":1596988800,"title_zh":"S-8 - Securities to be offered to employees in employee benefit plans","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"10227766","market":"us","labels":[],"media":"sec.gov","original_id":"AN87401520000115-IONS","pdf_url":null,"pub_time":1596556800000,"showTitleType":true,"size":0,"source":"sec_us","summary":"10-Q - Quarterly report [Sections 13 or 15(d)]","symbol":"IONS","title":"10-Q - Quarterly report [Sections 13 or 15(d)]","titleType":"季度報告","type":"usFinancials","url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000115/0000874015-20-000115-index.htm","us_notice_code":"Form 10-Q","us_title_en":"10-Q - Quarterly report [Sections 13 or 15(d)]","is_important":0,"hasEarnInfos":true,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"IONIS PHARMACEUTICALS INC 10-Q 6-30-2020","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000115/form10q.htm","primary":true,"translateUrl":null,"linkName":"form10q.htm","type":"10-Q","id":"NTFILE8nfv3HPdjjPkYQ4n","market":"us","size":2711698},{"description":"EXHIBIT 10.1","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000115/ex10_1.htm","primary":false,"translateUrl":null,"linkName":"ex10_1.htm","type":"EX-10.1","id":"NTFILE8SSgCQRRPE6PnmHv","market":"us","size":6537},{"description":"EXHIBIT 10.2","seq":3,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000115/ex10_2.htm","primary":false,"translateUrl":null,"linkName":"ex10_2.htm","type":"EX-10.2","id":"NTFILE5GGEtcCEJc8Wmuok","market":"us","size":42752},{"description":"EXHIBIT 31.1","seq":4,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000115/ex31_1.htm","primary":false,"translateUrl":null,"linkName":"ex31_1.htm","type":"EX-31.1","id":"NTFILE4YhCJHvKGE2xx1YY","market":"us","size":13545},{"description":"EXHIBIT 31.2","seq":5,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000115/ex31_2.htm","primary":false,"translateUrl":null,"linkName":"ex31_2.htm","type":"EX-31.2","id":"NTFILE7jAkVtkkzCa3yXo3","market":"us","size":13394},{"description":"EXHIBIT 32.1","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000115/ex32_1.htm","primary":false,"translateUrl":null,"linkName":"ex32_1.htm","type":"EX-32.1","id":"NTFILEFChMaWooo1Rv21K1","market":"us","size":6948},{"description":"XBRL TAXONOMY EXTENSION SCHEMA","seq":7,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000115/ions-20200630.xsd","primary":false,"translateUrl":null,"linkName":"ions-20200630.xsd","type":"EX-101.SCH","id":"NTFILE2woyNS3z7cueYr54","market":"us","size":46977},{"description":"XBRL TAXONOMY EXTENSION CALCULATION LINKBASE","seq":8,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000115/ions-20200630_cal.xml","primary":false,"translateUrl":null,"linkName":"ions-20200630_cal.xml","type":"EX-101.CAL","id":"NTFILEFFAfyJcAXhyE6Ps1","market":"us","size":68911},{"description":"XBRL TAXONOMY EXTENSION DEFINITION LINKBASE","seq":9,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000115/ions-20200630_def.xml","primary":false,"translateUrl":null,"linkName":"ions-20200630_def.xml","type":"EX-101.DEF","id":"NTFILEFaiU3TpXERUqqosr","market":"us","size":301998},{"description":"XBRL TAXONOMY EXTENSION LABEL LINKBASE","seq":10,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000115/ions-20200630_lab.xml","primary":false,"translateUrl":null,"linkName":"ions-20200630_lab.xml","type":"EX-101.LAB","id":"NTFILEGvUX5dPjbYsdvAzv","market":"us","size":717001},{"description":"XBRL TAXONOMY EXTENSION PRESENTATION LINKBASE","seq":11,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000115/ions-20200630_pre.xml","primary":false,"translateUrl":null,"linkName":"ions-20200630_pre.xml","type":"EX-101.PRE","id":"NTFILEEyym6oLBaDq9ZZW4","market":"us","size":413462},{"description":"EXTRACTED XBRL INSTANCE DOCUMENT","seq":12,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000115/form10q_htm.xml","primary":false,"translateUrl":null,"linkName":"form10q_htm.xml","type":"XML","id":"NTFILEEwotegDtYyZS7edn","market":"us","size":2334808}],"type_name":"財務報告","type_name_en":"Financial Report","titleTypeEn":"Quarterly Report","us_type":"usFinancials","us_type_zh":"財務報告","earn_infos":[{"id":21334,"name":"CONDENSED CONSOLIDATED BALANCE SHEETS (Unaudited)","name_zh":null,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000115/R2.htm","cdn_url":"","translation_url":"","translate_status":0},{"id":21335,"name":"CONDENSED CONSOLIDATED BALANCE SHEETS (Unaudited) (Parenthetical)","name_zh":null,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000115/R3.htm","cdn_url":"","translation_url":"","translate_status":0},{"id":21336,"name":"CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS (Unaudited)","name_zh":null,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000115/R4.htm","cdn_url":"","translation_url":"","translate_status":0},{"id":21337,"name":"CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME (LOSS) (Unaudited)","name_zh":null,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000115/R5.htm","cdn_url":"","translation_url":"","translate_status":0},{"id":21338,"name":"CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (Unaudited)","name_zh":null,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000115/R6.htm","cdn_url":"","translation_url":"","translate_status":0},{"id":21339,"name":"CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited)","name_zh":"簡明合併現金流量表（未經審計）","url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000115/R7.htm","cdn_url":"https://static.tigerbbs.com/0e87fc1d91f2aa9b812d801ba4836993","translation_url":"https://static.tigerbbs.com/e5aead93e65fe72566bec65d47b7e36f","translate_status":1}],"event_type":"important_notice","event_name":"季度報告","pubTime":"2020-08-05 00:00","pubTimestamp":1596556800,"title_zh":"10-Q - Quarterly report [Sections 13 or 15(d","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"10225960","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036120017532-IONS","pdf_url":null,"pub_time":1596556800000,"showTitleType":true,"size":0,"source":"sec_us","summary":"8-K - Current report","symbol":"IONS","title":"8-K - Current report","titleType":"重要事件披露","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036120017532/0001140361-20-017532-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 2.02: Results of Operations and Financial Condition;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"EXHIBIT 99.1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120017532/brhc10014107_ex99-1.htm","primary":true,"translateUrl":null,"linkName":"brhc10014107_ex99-1.htm","type":"EX-99.1","id":"NTFILE7MYikNDzDwRq7uGc","market":"us","size":422287},{"description":"8-K","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120017532/brhc10014107_8k.htm","primary":false,"translateUrl":null,"linkName":"brhc10014107_8k.htm","type":"8-K","id":"NTFILEFcDyqksXELMyEPS1","market":"us","size":25381},{"description":"XBRL TAXONOMY EXTENSION SCHEMA","seq":3,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120017532/ions-20200805.xsd","primary":false,"translateUrl":null,"linkName":"ions-20200805.xsd","type":"EX-101.SCH","id":"NTFILE2nnoYcWVeDpZ9fHm","market":"us","size":4198},{"description":"XBRL TAXONOMY EXTENSION LABEL LINKBASE","seq":4,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120017532/ions-20200805_lab.xml","primary":false,"translateUrl":null,"linkName":"ions-20200805_lab.xml","type":"EX-101.LAB","id":"NTFILEEb3wtjYaF9c3JFti","market":"us","size":22718},{"description":"XBRL TAXONOMY EXTENSION PRESENTATION LINKBASE","seq":5,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120017532/ions-20200805_pre.xml","primary":false,"translateUrl":null,"linkName":"ions-20200805_pre.xml","type":"EX-101.PRE","id":"NTFILEBYzzXkCW8EvpP4Qg","market":"us","size":16218},{"description":"","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120017532/image0.jpg","primary":false,"translateUrl":null,"linkName":"image0.jpg","type":"GRAPHIC","id":"NTFILEEFm16q1PJu9QDzwr","market":"us","size":11774},{"description":"EXTRACTED XBRL INSTANCE DOCUMENT","seq":7,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036120017532/brhc10014107_8k_htm.xml","primary":false,"translateUrl":null,"linkName":"brhc10014107_8k_htm.xml","type":"XML","id":"NTFILE4sRmj1GQRshkQTxF","market":"us","size":4078}],"type_name":"交易披露","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"usAnnouncement","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"重要事件披露","pubTime":"2020-08-05 00:00","pubTimestamp":1596556800,"title_zh":"8-K - Current report","summary_en":"Item 2.02: Results of Operations and Financial Condition;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"第2.02項:經營成果和財務狀況； 項目9.01:財務報表和報表","notice_type":"","filling_tag":"","gpt_icon":0}],"pageSize":20,"totalPage":22,"pageCount":17,"totalSize":426,"code":"91000000","status":"200"}]}}